Crumbs Bake Shop has closed in downtown Boston — again.

The New York City-based bakery and cupcake chain had previously shuttered its location at 176 Federal St. in Boston’s Financial District in July 2014, only to be reopened months later after filing for Chapter 11 bankruptcy protection.

But this time, the chain’s bricks-and-mortar store appears shuttered for good. The storefront is empty, with all equipment removed, and a bright-red “for lease” sign posted in the window.

Emily Ou…